Twenty thousand data runs
and no statistically SIGNIFICANT results.
The Big Bang Theory Season 2, Episode 13
...with his dating a woman
whose most SIGNIFICANT achievement...
The Big Bang Theory Season 3, Episode 11
...I'm going to go do work
that promises SIGNIFICANT results...
The Big Bang Theory Season 2, Episode 2
I owe you a SIGNIFICANT debt.
Game of Thrones Season 3, Episode 3
with his SIGNIFICANT other.
The Big Bang Theory Season 7, Episode 5